No claims are made regarding therapeutic, diagnostic, or biological suitability beyond research use
From a therapeutic standpoint, pharmacological inhibition of SLFN4 either through small molecules like sildenafil or genetic approaches has demonstrated efficacy in preclinical models
Combining antiangiogenic agents, such as saikosaponin b2 which targets the VEGF/ERK/HIF-1 pathway, with immunotherapy enhances treatment efficacy
Taking its name from the Greek name "Karren" (meaning "pureness"), CARE:NEL advocates respect for Mother Nature by avoiding artificial ingredients and animal testing
It works through the same core pathways as the rest of the centella family
Ferroptosis A form of programmed cell death that is dependent on intracellular iron, characterized by the intracellular accumulation of lipid peroxides