Even at moderate doses, some individuals may be more sensitive than others
Multiple metabolic reactions in the body are needed to convert NAC into glutathione
This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)
However, not all glutathione products are created the same
Ptak G, Loi P, Dattena M, Tischner M, Cappai P
D-alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract