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By improving glucose removal in white adipose tissue, tirzepatide restored insulin sensitivity even when there was no GLP- 1 receptor -induced weight loss

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Split dosing becomes valuable when single dosing produces inconsistent results, when doses above 400mcg are needed, or when evening administration fits better into lifestyle patterns

In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [2]

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