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44 The 52-week data from 966 patients with MASH and F1B, F2, or F3 fibrosis in the MAESTRO-NASH trial revealed significant effects of resmetirom on MASH resolution, fibrosis improvement, and LDL cholesterol reduction (NCT03900429), 77 forming the basis for potential FDA approval of resmetirom for MASH treatment

J Appl Physiol 113:15761584 De Cecco M, Criscione SW, Peckham EJ, Hillenmeyer S, Hamm EA, Manivannan J, Peterson AL, Kreiling JA, Neretti N, Sedivy JM (2013) Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

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210,211 The activation of NF-B signaling is usually initiated by external stimuli such as cytokines or bacterial lipopolysaccharides, which bind to their corresponding receptors and trigger downstream signaling pathways

Mitophagy serves as the critical defensive mechanism preventing these mitochondrial insults from overwhelming neurons