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Jump to: Why retatrutide isnt on the NHS yet | The realistic UK timeline | What NHS access is likely to look like | What to do in the meantime | Comparing private and NHS access | Frequently asked questions | Take home message | References You cant get retatrutide on the NHS in the UK as of 2026

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These interactions strengthen the binding and function of GLP-2, consistent with the decreased potencies of R242A (by 5-fold), R242E (by 20-fold), W249A (by 1552-fold) and Y252A (by 5-fold) (Fig

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Therefore, decreased DPP-4 activity is unlikely to explain the elevated GLP-1 levels after metformin treatment

It is currently in a phase-3 trial, which is set to finish by early 2026