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The Negatives: What the Trials Showed Across programs like STEP, SURMOUNT, and SELECT, side effects were largely gastrointestinal: Nausea, vomiting, constipation, diarrhea
Microdosing semaglutide means starting treatment at a fraction of the standard dose, typically 0.10.25 mg weekly, then advancing based on tolerability and response
Saxenda requires gradual titration from 0.6 mg daily up to the maintenance dose of 3.0 mg daily over five weeks
(2024c, April 20)
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