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Indeed, diet-induced weight loss in knee or hip OA patients has previously been shown to slow disease progression, improve joint function, and reduce joint pain [79]

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These studies underscore that the effects of serine might depend on the type of infiltrating immune cells (Tregs or Teffs) and their specific isomer, being an interesting target for supplementation in tumors with a high ratio of infiltrated Teffs/Tregs

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