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The individual side effect rates (nausea, vomiting, diarrhea) are similar between the two compounds, but the discontinuation rate, which reflects how many people find the side effects intolerable, is significantly lower for semaglutide (5-7%) compared to retatrutide (12-18%)

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And if fiber alone isn't cutting it, a combination of magnesium and fiber gives you a stronger foundation to work from

Until recently, no therapeutic potential was associated with the other incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), as preclinical studies have suggested potential obesogenic effects

Therefore, endogenous GIP seems to retain a role in postprandial glucose regulation following gastric sleeve but when the first part of the small intestine is bypassed (Roux-en-Y gastric bypass) endogenous GIP does not contribute to the postprandial glucose regulation (79)