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Transcriptomic profiling of the Taxol-resistant cells revealed 112 genes with pronounced overexpression, among which FKBP5 exhibited an initial 100-fold upregulation during resistance acquisition, followed by a decline with extended culture

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doi: 10.1016/S1472-6483(10)60312-4 218 TremellenKMiariGFroilandDThompsonJ

The reason for this can be anything from patient therapeutic response to objectives, but most of the time, it can get injected 2-3 times a week

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