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However, in vivo studies on the chemopreventive activity of SFN in HCC are very limited

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Mattis and Sehgal 2016)

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The delivery of PDCs into tumor cells via tumor-homing peptides can exert a tumoricidal effect in the intracellular compartments of tumor cells where tumor-specific pH or enzymes can break the linkers, releasing the drugs

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LY3437943 has shown a powerful effect in reducing liver fat and liver injury markers in obese mice, which may be attributed to a combination of GCGR's direct impact on the liver or the indirect effects resulting from weight loss

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