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Excess body fat has been linked to a myriad of health issues, including cardiovascular disease, diabetes, and certain types of cancer

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To overcome these limitations, in this study, we describe the rational design, synthesis, and in-depth biological assessment of ruthenium (Ru)-containing nanoreactors for the catalytic oxidation of GSH to GSSG in hypoxic osteosarcoma

Hence targeting the XRCC4/Lig4 assembly could produce a double effect through both inhibition of NHEJ and of rescuing DSB repair pathways by blockage of DNA-PK at DNA ends 17,18

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