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TRPM8 agonists activate trigeminal nerve signaling, leading to increased basal tear production
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Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts
Further, Xavier noted that she and her colleagues did not assess possible psychiatric side effects with these drugs in the studies they reviewed, so they could not say that these GLP-1 receptor agonists were completely safe in their own findings
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Regulatory and safety status: Epitalon is currently awaiting FDA review
