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In OSKM as compared to WT mice, we saw significant depletion of all four of these amino acids (Gly, Ser, Thr and Met), concomitant with an increase in SAM and an increase in the SAM/Met ratio, progressively over the course of reprogramming (Fig

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Investigation Areas Dilution and reconstitution studies (laboratory only) Aqueous excipient compatibility and stability screening Container/closure interaction assessments Device priming and flush procedures (non-clinical) General wet-lab solution preparation Handling Requirements Qualified personnel in equipped laboratories Use aseptic technique

Individuals should consult a qualified healthcare professional before beginning any peptide protocol