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The symptoms of a more severe deficiency include anemia, which presents as fatigue, pale skin color, shortness of breath, and lightheadedness

39 Another study demonstrated that after 6 months, the combination of FCS with mini-punch grafting (a tissue-cellular hybrid approach) yielded significantly better repigmentation than either technique alone, highlighting the additive benefit of incorporating follicular-derived cells

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Additionally, HGF/c-Met signaling regulates the NADPH oxidase system, initiating an Nrf2-mediated protective response