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However, we found low heterogeneity between the five trials in all-cause mortality (I 2 = 22%) (Figure 2) and detected no heterogeneity between the two trials reporting heart failure (I 2 = 0%), unstable angina (I 2 = 0%), and myocardial reinfarction (I 2 = 0%) (Figure 3)

Overall, this trial was designed to precisely determine the dose-response relationship, efficacy, and safety of Cagrilintide compared with placebo and liraglutide, while employing advanced statistical methods to ensure reliable interpretation of treatment effects under both ideal and real-world adherence conditions

(PubMed) Borrelli F, Capasso R, Izzo AA