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Safety data in humans is not as robust as it is for FDA approved medications

Greene says

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previous episodes of jaundice Risk factors : Female sex, age over 40, obesity, rapid previous weight loss, pregnancy history, family history of gallstones, certain ethnicities (Native American, Hispanic heritage) Physical examination : Right upper quadrant tenderness, Murphy's sign (inspiratory arrest during right subcostal palpation) Laboratory testing : Liver function tests may be considered based on clinical judgment to establish baseline and screen for biliary obstruction Imaging considerations : Routine abdominal ultrasound before starting weight loss injections is not recommended for asymptomatic patients

Acetate buffer (pH 4-5) or water (pH 5-7) are recommended

Roberts M, Tolar-Peterson T, Reynolds A, Wall C, Reeder N, Rico Mendez G