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In pancreatic beta cells, GLP-1 receptor activation enhances glucose-stimulated insulin secretion
Additionally, the crystallizable fragment (Fc) of mAbs can interact with cell surface receptors (FcR), sometimes leading to excessive lymphocyte activation, which may cause side effects, such as cytokine storms 6,7
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CagriSema may become an important Novo Nordisk follow-up platform if the amylin-plus-GLP-1 combination proves durable and tolerable
Always consult a qualified healthcare professional before starting any prescription treatment program
Tech transfer requires cross-validation of HPLC/LC-MS methods so impurities and host-cell proteins are measured the same way in both sites
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