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Cessation stops the active stimulus, but the existing deposits of melanin in the tissue do not clear spontaneously in most cases
Why 2mg is the Current Ceiling Clinical trials for Ozempic, such as the SUSTAIN FORTE trial, specifically looked at the safety and efficacy of moving from a 1mg dose to a 2mg dose
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Perkins, who was not involved in the trials
There is also a theoretical concern observed in rodent studies with GLP-1 agonists regarding thyroid C-cell changes, though this has not been confirmed in humans and is not established as a contraindication in UK GLP-1 receptor agonist prescribing information
Dulaglutide and liraglutide are older GLP-1 agents with less robust weight loss efficacy than newer compounds
