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Although current recommendations for Se therapy extend only to GO patients, Se supplementation has been widely used by clinicians for a variety of other thyroid disorders

These combined metabolic shifts can make the body feel colder, especially in the first weeks of treatment before adaptation occurs

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However, most large-scale clinical trials of semaglutide (including the STEP trials for weight loss) used the standard once-weekly schedule, so direct evidence comparing weekly versus twice-weekly dosing remains limited in the published literature

These physiological and psychological changes may contribute to emotional lability or depressive symptoms in susceptible individuals