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Recently, the scientific breakthrough, clustered regularly interspaced short palindromic repeats (CRISPR)-Cas (CRISPR associated protein) system has gained momentum for genome editing in plants

doi: 10.1186/s12916-016-0681-8 21 HeZLuoQLiuZGongL

doi: 10.1038/s41579-020-0433-9

A.Sanchez-SalasR.PeskeJ

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Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models