Two collagen types dominate: Type I collagen (mature tendon structure) Type III collagen (early repair phase) In rodent studies, BPC-157-treated tendons showed: Increased type I collagen deposition Improved fiber parallel alignment Better biomechanical strength This suggests influence over: TGF- signalling Matrix metalloproteinases (MMPs) Extracellular matrix remodelling enzymes Balanced ECM remodelling prevents disorganized scar tissue
10.1186/s12885-020-07457-1 20 PlouffeB
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Some studies indicate that short-term infliximab treatment (14 weeks) decreases both bone formation markers, such as osteocalcin, and bone resorption markers, such as N-terminal telopeptide (NTX) (87)