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Warnings and Precautions 5.1 Risk of Thyroid C-Cell Tumors In rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]

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Sep 2018;22(3):841-851

This lipotropic injection is commonly used in weight management programs to potentially support metabolism and energy levels

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Furthermore, 24-h ambulatory monitoring indicated that setmelanotide did not induce increases in heart rate or blood pressure, pointing to favorable cardiovascular safety [55]