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Gradual dose titration : Following the prescribed dose escalation schedule is essentialrushing titration significantly increases side effect severity
HFpEF is characterized by the presence of different comorbidities such as type-2 diabetes mellitus (T2DM), visceral obesity and ageing, all contributing to systemic metabolic inflammation [7, 8]
Biochem Biophys Res Commun 495:4652 Lukey MJ, Greene KS, Erickson JW, Wilson KF, Cerione RA (2016) The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
Other options include pasireotide (which requires blood glucose monitoring due to hyperglycaemia risk), metyrapone , or ketoconazole (used off-label for Cushing's with liver function monitoring)
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