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10.1016/j.heliyon.2018.e00508 Heliyon 41 GuoS.WangH.YinY

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Compared with the rats treated with APAP alone, rhein treated animals demonstrated significant reduction of the biochemical indicators of liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea nitrogen (UREA), creatinine (CREA), nitric oxide (NO), and malondialdehyde (MDA)

As the body gets older, glutathione levels typically decrease

But it is currently classified as a cosmetic product, meaning there is no need for it to undergo the safety testing required for medical devices

Developed by Eli Lilly, it is a 39-amino-acid synthetic peptide with a C20 fatty diacid side chain attached via a linker at lysine-20, enabling binding to albumin for once-weekly dosing pharmacokinetics (Jastreboff AM et al., NEJM 2022