The closest thing to an evidence-based loose skin protocol is: adequate protein, resistance training, gradual weight loss when possible, sun protection, retinoids for facial use, topical GHK-Cu as adjunct, hydration, and patience
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Microbial metabolites, such as SCFAs and lipopolysaccharides (LPS), may affect gut permeability, systemic inflammation, and neural function
Note that meningeal macrophages (green
Histology may show inflammation (cholestatic hepatitis) or it can be bland (without any parenchymal inflammation)
Its especially known among those trying to lose weight