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Any improvements in calorie burning are more likely related to increased physical activity and exercise consistency rather than a direct effect on metabolic rate

Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Torne CW, Ryan DH

559 These predictions inform rational design of combination therapies that strategically exploit compensatory relationships rather than acting blindly upon isolated mechanisms

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For multi-institution or multi-investigator research programs, a standardized blend from a single supplier also improves between-laboratory reproducibility

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