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The clinical trials highlighted significant weight reduction in participants, with an acceptable safety profile

Weight regain is common after discontinuation, particularly if lifestyle modifications are not maintained

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Gulak and Murphy 2023

N Engl J Med (2018) 379(7):63344

If those levels drop too quickly, the period of metabolic adjustment can make cells vulnerable to injury. But a rapid drop in blood sugar likely isnt the mechanism associated with NAION, since most cases of blindness happen many months after starting the medication