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Successively, it was shown that TIGAR, a protein involved in the inhibition of the glycolytic pathway, could limit starvation-induced ATG by means of its ability to indirectly suppress ROS production (Deffieu et al., 2009)

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Adicionalmente, la sibutramina produce un aumento de la frecuencia cardaca y la presin sangunea, que pueden provocar arritmias, cardiopatas isqumicas y accidentes vasculares graves en algunos pacientes