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In SURPASS-4, Mounjaro lowered patient weight by 14 pounds (5 mg), 20 pounds (10 mg), and 23 pounds (15 mg) compared to a gain of 4 pounds with insulin glargine

For those wondering about the full picture, our guide on how long to stay on semaglutide covers the clinical recommendations

Hong et al (136) found that Ex-4 improved muscle atrophy by inhibiting the expression of myostatin and muscle atrophy factors, while enhancing muscle growth factors through the GLP-1R-mediated signaling pathway

Not everything about Wegovy and Mounjaro is different

If your doctor evaluates your heart disease risk based on lipid panels, the improvements from tirzepatide could shift your risk category