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Then researchers noticed that people taking them lost significant weight

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Is it the [00:39:00] animals or the humans

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org

While these drugs, which mimic the effects of the hormone GLP-1 by slowing stomach emptying and promoting a feeling of fullness, are often viewed as a quick solution, rapid weight loss is associated with bone density reduction, as the reduced load the weight, pressure or stress your bones have to bear decreases the need to form new skeletal tissue, as the more pressure on your bones, the more your bones are forced to become stronger

By activating the same receptors the natural hormone uses, they reproduce its appetite-regulating and metabolic effects at a clinical level