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Saxenda on the other hand is usable in adulthood and adolescence
Jacobsen LV, et al
How to manage it: Start with a lower dose and increase gradually, as prescribed by your doctor
In summary, whilst early clinical trial data for retatrutide is promising, it remains an investigational medicine with an incompletely characterised safety profile
The question is not which dual agonist approach is universally better, but which second-receptor mechanism best serves specific patient populations and metabolic goals
Ethics declarations Competing interest DY received clinically commissioned/joint research grants from Novo Nordisk, Ono Pharmaceutical, Taisho Pharmaceutical, Terumo, and Arklay
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