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Typically, the patient administers the shot themselves at home, but this can also be done in a clinic setting

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Office-based treatments are effective for grades I, II, and some grade III hemorrhoids

Clinical evidence suggests that whilst these medicines do not directly damage the eyes, they may be associated with worsening diabetic retinopathy in certain patients, particularly those with pre-existing eye disease who experience rapid improvements in blood glucose control

Pfizer discontinued the twice-daily formulation in December 2023 due to gastrointestinal side effects and high discontinuation rates

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