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The GSH to glutathione disulfide ( GSSG ) ratio is a key indicator of cellular oxidative stress, highlighting the importance of maintaining balanced levels

Due to their expression of oncogenes, cancer cells are more susceptible to the effects of fasting and CR than are normal cells, an effect termed differential stress resistance
Garcia, D

Int J Mol Med 47:11071156 Lohrasbi P, Karbalay DS, Tabei SMB, Azarpira N, Alaee S, Rafiee B, Bahmanpour S (2022) Melatonin & metformin in PCOS mice

There are no current recommendations to stop the medication in men trying to conceive and any negative impact should resolve within 70 days of stopping the medication
