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Sourcing note Tirzepatide can be prescription (Mounjaro/Zepbound) or research-use

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If cold sensitivity is associated with chest pain, severe breathlessness, or fainting, call 999 immediately as this could indicate cardiovascular concerns that need urgent evaluation

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Patients are advised to stay hydrated

The maximum in-use shelf life is 28 days after initial puncture, provided strict aseptic technique is maintained at every access