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It may be a fit for patients who: Have appetite regulation challenges Have signs of insulin resistance Have struggled with repeated weight loss attempts Need stronger metabolic support Have not responded as expected to other approaches Have a medical history that supports tirzepatide use Can tolerate the medication appropriately Tirzepatide may be appealing because of its dual-hormone mechanism, but stronger does not always mean better for every person

Patients had a mean age of 56 years and 52% were men

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doi:10.1056/NEJMoa2107519 Wadden TA, Bailey TS, Billings LK, et al