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Chenomx NMR suite 9.0 (Chenomx Inc., Edmonton, AB, Canada) was used for metabolite detection and quantification

At 60 h post-injection, the mice were euthanized in order to collect tumor tissues and major organs for subsequent ex vivo imaging

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Exercise Recumbency Training A carefully structured, gradually progressive exercise program beginning with recumbent exercises (swimming, recumbent biking, rowing) can help recondition the autonomic nervous system

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Aim for at least 30 minutes of moderate exercise most days of the week