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Community protocols describe gradual dose escalation rather than a loading phase

Injections that need to reach deep muscle tissue may benefit from using a needle designed to penetrate barriers easily, such as the RELI Safety Hypodermic Needle with Pre-attached Luer Lock Syringe , that comes in a variety of sizes

[1] Use a new sterile needle and syringe for each withdrawal (multi-dose vial technique), and swab the rubber stopper with alcohol

For B12 deficiency, a typical injection dose is 1,000 mcg once a week for 4 to 8 weeks and then 1,000 mcg once a month

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Lebers disease (hereditary optic nerve atrophy) Polycythemia vera Low potassium levels (hypokalemia) History of blood clots Preparation Details Avoid alcohol when receiving B12 shots