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GLP-1 use is happening around us, whether we like it or not
In rodents, the thyroid C-cells (neuroendocrine parafollicular cells which secrete calcitonin) highly express the GLP-1 receptor ( In the SUSTAIN program, three adjudicated events of malignant thyroid neoplasm were identified, two in semaglutide-treated patients (combined n = 5,933), and one in the comparator group (n = 4,736) ( versus one in the comparator group ( It should be noted that MTC is rare (estimated incidence of 0.2 cases per 100,000 patient-years), and as such, it is very difficult to definitively rule out an association between GLP-1RA and thyroid malignancies
But if youre barely able to eat because your appetite is completely gone, your dose may be contributing to the problem
This is bad because muscle is what burns calories
The entire process was smooth and comfortable
