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It targets dopamine-serotonin interactions in motor-reward circuits rather than the traditional raphe-cortex pathway targeted by SSRIs

J Clin Endocrinol Metab 88:46964701 Santoprete A, Capito E, Carrington PE et al (2011) DPP-IV-resistant, long-acting oxyntomodulin derivatives

IGF-1 LR3 was developed as a more potent version of insulin-like growth hormone-1, as it has better stability and efficiency for stimulating cell growth during in vitro experiments

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Such nitration-dysfunction is specific to HGF among other major growth factors examined (FGF2, IGF1, and TGF-2), highlighting the inhibitory impact of accumulation of nitrated HGF on myogenic stem cell biology during aging 32