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The larger surface area can make physical discomfort more pronounced than after smaller facial treatments

The most prevalent reactive species detected in the PTLs are hydrogen peroxide (H 2 O 2 ), nitrites (NO 2 ) and nitrates (NO)

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The lack of nutrients also leads to the depletion of reducing agents like glutathione and thus to the overall reduction of antioxidative capacity in hepatocytes

References: Dimova, S., Hoet, P