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Class warnings for thyroid C-cell tumors apply
Carbohydrate timing also matters, particularly for women using growth hormone secretagogues
52 Contraindications GLP-1RAs are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia syndrome type 2
Patients should be counseled on realistic weight loss expectations (515% body weight over 612 months), common side effects (nausea, constipation), and the importance of lifestyle continuity
Given this dilemma, shifting focus to alternative weight loss therapies that do not rely on the leptin-melanocortin system - such as GLP-1 RAs, which have distinctly different mechanisms of action - may offer theoretical feasibility for the treatment of MC4R -deficient obesity
Most GLP-1 medications can be stored at room temperature for product-specific durations (14 days to 6 weeks), so a single overnight period is typically acceptable if within this timeframe
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