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Inflammatory cell infiltration follows tissue injury, initially serving protective functions but potentially causing secondary damage if prolonged or excessive

doi: 10.3945/ajcn.2009.28169 201

ISSN 0022-2143

However, despite the clinical evidence that serum E2 levels are inversely correlated with psoriasis severity, and replacement therapy with low-dose E2 administration in may improve psoriasis, tamoxifen, an antiestrogen agent, results in the remission of psoriasis, thus suggesting that estrogens might exert both pro-inflammatory and anti-inflammatory effects in psoriasis [124]

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