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Oxygen in the headspace accelerates copper oxidation
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For example, kynurenine restrains melanoma and endothelioma cellular proliferation [136, 137], impairing DNA synthesis and inducing necrosis in melanoma cells, while promoting the -catenin pathway and colon cancer cells multiplication in a dose-dependent manner [138]
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However, it is crucial to emphasize that this rationale derives entirely from separate preclinical studies of individual peptides, not from controlled investigation of the three-peptide combination
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