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Injection of GLP-1 directly into the central nucleus of the amygdala (CeA) of rats results in CTA (Kinzig et al., 2002) whereas injection into the PVN reduces food intake without eliciting CTA (McMahon and Wellman, 1998)

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Indeed, GIPR agonism can blunt the nauseating effects of GLP-1R agonists in humans (52)

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