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Mechanistically, L-tryptophan upregulated the expression of GLP-1related genes (e.g., Gcg and Pcsk1 ) in intestinal L cells, further promoting GLP-1 production ( In contrast, some postbiotics may suppress GLP-1 signaling

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While this observational study cannot prove causation, it raises important questions about whether GLP-1s could become part of future strategies for substance use disorders, overdose prevention, and post-overdose care management