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Instead of adding amino acids, DES removes the first three from the N-terminus, creating a truncated 67 amino acid peptide

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Ann Oncol 24(5):1262-6, 2013

But with a 2mg/mL concentration (5mL of water added), that same 4mg dose requires 2.0mL of liquid, which is an entire insulin syringe worth and creates a large, uncomfortable injection volume

103 However, Wnt3a is reported to be capable of activating transcriptional coactivator with PDZ-binding motif (TAZ), which can directly upregulate IRS-1, indicating its potential ability of increasing insulin sensitivity in muscle

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