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Genetic variants in carnitine-related genes (SLC22A5, CPT1, CPT2) can cause disorders that affect energy production, causing issues from mild fatigue to severe dysfunction
Dedicated urate-lowering therapy such as allopurinol or febuxostat remains the mainstay treatment for hyperuricaemia and gout, in line with NICE guidance
The most common side effects of injectable tirzepatide include nausea, diarrhoea, vomiting, decreased appetite, abdominal discomfort, constipation, and dyspepsia
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In the SURMOUNT-1 obesity trial, participants achieved weight loss averaging up to approximately 21% of baseline body weight at 72 weeks with the 15 mg dose
