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Upon CNS invasion, activation of the glucose repression regulator Mig1 has been linked to enhanced AmB tolerance (Chen et al., 2024)
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
As Mounjaro usage continues to grow for both diabetes management and weight loss in the UK, increased awareness of this side effect will help patients prepare appropriately
Moreover, apart from the unambiguous identification of the phosphopeptide sequence, the deconvoluted tandem mass spectra should contain sufficient information to localize phosphorylation sites with single amino acid resolution 1
Environ Res 273:121251
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