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Description

Semaglutide 2.4mg (Wegovy) is commissioned by the NHS only through specialist weight management services, with specific eligibility criteria (including BMI thresholds, which are lower for people from some ethnic groups) and a maximum treatment duration of 2 years

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It induces direct cardiomyocyte toxicity: adult rat ventricular myocytes exposed to 20100 M TMAO show a 2628% reduction in fractional shortening, a 3147% decrease in maximal shortening/relengthening rates, and a 1320% prolongation of calcium removal time (Savi et al., 2018)

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