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Troke RC, Tan TM, Bloom SR
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The role of liver-derived insulin-like growth factor-I
Its pharmacological signature potent GHS-R1a-mediated GH release with negligible off-target stimulation of cortisol, prolactin, or ACTH at research-relevant concentrations makes it the ghrelin receptor agonist of choice for investigators requiring isolated GHS-pathway activation without confounding neuroendocrine variables
Tirzepatide (Mounjaro, Zepbound) Tirzepatide belongs to a different class of drugs called dual-action GLP-1/GIP receptor agonists
Hypoglycaemia (low blood sugar) is uncommon with Wegovy alone but may occur if you are taking other diabetes medications concurrently, particularly insulin or sulphonylureas
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